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KMID : 0604520100360020151
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Journal of the Society of Cosmetic Scientists of Korea
2010 Volume.36 No. 2 p.151 ~ p.156
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Modulatory Effect of Four Azulene Derivatives from the Fruiting Bodies of Lactarius hatsudake on Interferon- Production
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Guang Hua Xu
Kim Jae-Wha
Gao Li
Yoo Ick-Dong
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Abstract
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Investigation of secondary bioactive metabolites from the fruiting bodies of Lactarius hatsudake led to the isolation of four azulene derivatives by means of repeated column chromatography and preparative HPLC, and they were identified as 1-formyl-4-methyl-7-isopropyl azulene (1), lactaroviolin (2), 4-methyl-7-isopropyl-azulene-1-carboxylic acid (3), and 1-formyl-4-methyl-7-(1-hydroxy-1-methylethyl) azulene (4) by their physico-chemical properties and spectroscopic analysis. The isolated compounds were evaluated for the effects on modulation of cytokines in natural killer cell line (NK92 cells). Compounds 1 and 4 strongly inhibited IFN- production in a dose-dependent manner, corresponding to 101.3 % and 92.7 % inhibition at 400 , and 11.9 % and 24.1 % at 100 , respectively, whereas compounds 2 and 3 showed weak inhibitory effect on INF- production, corresponding to 45.9 % and 18.0 % inhibition at 400 .
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KEYWORD
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Lactarius hatsudake, azulene, interferon-, natural killer cell
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